Predictive Toxicology and Exploratory Biology

Advancing Toxicology Testing and Pharmaceutical Development Through NAMs

In research, the shift to using in vitro and computational new approach methodologies (NAMs) can decrease our reliance on animal testing, while increasing the human relevance of toxicity testing, pre-clinical pharmaceutical development, and basic science research. By pairing human-derived in vitro systems with different testing methods that are more relevant to humans, investigators can see how substances impact the human body. 

This approach allows us to discover how potential toxins or therapeutics affect human health down to the cellular and molecular level and understand how these effects may differ across the diverse human population. From there, we can apply cutting-edge computational modeling and analytical approaches such as in vitro to in vivo extrapolation (IVIVE) to interpret lab results and make important, life-saving predictions on how harmful or beneficial a substance might be for the public. 

High-Throughput Screening: A Key Component of Our Approach

High-Throughput Screening (HTS) is a cornerstone of our approach at RTI, which allows us to quickly test many substances to see if they are toxic by using different cell types. Our multidisciplinary team emphasizes the importance of assay development, assessment, and transferability to make sure tests are reliable and applicable across a variety of contexts for clients and partners, encompassing the full spectrum of NAMs expertise.