Ann Decker

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Novel peripherally selective cannabinoid receptor 1 neutral antagonist improves metabolic dysfunction-associated steatotic liver disease in mice

Design, synthesis, and structure–activity relationship studies of novel GPR88 agonists (4-substituted-phenyl)acetamides based on the reversed amide scaffold

Fluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity

In vitro and in vivo evaluation of pellotine: A hypnotic lophophora alkaloid

Discovery of 1,3-disubstituted pyrazole peripheral cannabinoid receptor partial agonists

High-throughput, microplate reader detection of the ASP+ fluorescent substrate to identify novel inhibitors of organic cation transporter-3

Improvement of the metabolic stability of GPR88 agonist RTI-13951-33: Design, synthesis, and biological evaluation

Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor

Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects

The GPR88 agonist RTI-13951-33 reduces alcohol drinking and seeking in mice

Role of GPR88 in ethanol drinking: A new pharmacological target

Identification of a potent human trace amine-associated receptor 1 antagonist

Neuropeptide B/W receptor 1 peptidomimetic agonists: Structure-activity relationships and plasma stability

Development of 3-(4-chlorophenyl)-1-(phenethyl)urea analogues as allosteric modulators of the cannabinoid type-1 receptor: RTICBM-189 is brain penetrant and attenuates reinstatement of cocaine-seeking behavior

Indole-containing amidinohydrazones as nonpeptide, dual RXFP3/4 agonists: Synthesis, structure–activity relationship, and molecular modeling studies

Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies

Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids

Discovery of arylsulfonamides as dual orexin receptor agonists

The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7

Validation of a high-throughput calcium mobilization assay for the human trace amine-associated receptor 1