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Results of the economic evaluation of the first study. A multinational prospective economic evaluation. FIRST Investigators. Flolan International Randomized Survival Trial
Schulman, KA., Buxton, M., Glick, H., Sculpher, M., Guzman, G., Kong, J., Backhouse, M., Mauskopf, J., Bell, L., & Eisenberg, JM. (1996). Results of the economic evaluation of the first study. A multinational prospective economic evaluation. FIRST Investigators. Flolan International Randomized Survival Trial. International Journal of Technology Assessment in Health Care, 12(4), 698-713.
We present the prospective economic evaluation that served as a secondary endpoint for the FIRST study, a randomized international multicenter trial of patients with severe congestive heart failure. Although the clinical results of this study were disappointing, we demonstrated the feasibility of incorporating prospective economic evaluation in phase III clinical trials
