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Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis
Manosuthi, W., Sungkanuparph, S., Anekthananon, T., Supparatpinyo, K., Nolen, T., Zimmer, LO., Pappas, PG., Larsen, RA., Filler, SG., Chetchotisakd, P., & BAMSG 3-01 Study Team, U. (2009). Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis. International Journal of Antimicrobial Agents, 34(5), 494-496. https://doi.org/10.1016/j.ijantimicag.2009.05.009
Azoles may cause prolongation of the QT interval either directly or by inhibiting the hepatic metabolism of other QT-prolonging agents [1] S. Wassmann, G. Nickenig and M. Böhm, Long QT syndrome and torsade de pointes in a patient receiving fluconazole, Ann Intern Med 131 (1999), p. 797. View Record in Scopus | Cited By in Scopus (33)[1] and [2]. Ketoconazole is known to block the human ether-a-go-go-related gene (hERG) product and thereby inhibit the potassium IKr current in the heart [3]. Whether fluconazole also inhibits hERG is currently unknown.
