Blood myo-inositol concentrations in preterm and term infants

Abhik Das; Kristin M. Zaterka-Baxter; Tracy Lynn Nolen; Daniel Joseph Zaccaro; Luc P Brion; Dale L Phelps; Robert M. Ward; Tracy Nolen; N. Mikko K. Hallman; Abhik Das; Daniel Joseph Zaccaro; M Bethany Ball; Kristi L. Watterberg; Ivan D. Frantz; C. Michael Cotten; Brenda Poindexter; William Oh; Ralph A. Lugo; Krisa P. Van Meurs; T Michael O'Shea; Kristin M. Zaterka-Baxter; Rosemary D. Higgins

Blood myo-inositol concentrations in preterm and term infants

Brion, L. P., Phelps, D. L., Ward, R. M., Nolen, T. L., Hallman, N. M. K., Das, A., Zaccaro, D. J., Ball, M. B., Watterberg, K. L., Frantz, I. D., Cotten, C. M., Poindexter, B. B., Oh, W., Lugo, R. A., Van Meurs, K. P., O'Shea, T. M., Zaterka-Baxter, K. M., Higgins, R. D., & Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (2021). Blood myo-inositol concentrations in preterm and term infants. Journal of Perinatology, 41(2), 247-254. https://doi.org/10.1038/s41372-020-00799-5

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Abstract

OBJECTIVE: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age.

DESIGN/METHODS: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values.

RESULTS: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants).

CONCLUSIONS: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.