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Showing results 1 to 20 of 55.
Article
Novel peripherally selective cannabinoid receptor 1 neutral antagonist improves metabolic dysfunction-associated steatotic liver disease in mice
September 13, 2024
Article
The monoacylglycerol lipase inhibitor ABX-1431 does not improve alcoholic liver disease
August 01, 2024
Article
Discovery of 1,3-disubstituted pyrazole peripheral cannabinoid receptor partial agonists
September 01, 2023
Article
Improvement of the metabolic stability of GPR88 agonist RTI-13951-33: Design, synthesis, and biological evaluation
February 23, 2023
Article
Structure-activity relationship development efforts towards peripherally selective analogs of the cannabinoid receptor partial agonist BAY 59-3074
September 02, 2022
Article
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor
July 15, 2022
Article
Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies
August 26, 2021
Article
"Photo-Rimonabant": Synthesis and biological evaluation of novel photoswitchable molecules derived from Rimonabant lead to a highly selective and nanomolar "Cis-On" CB1R antagonist
May 05, 2021
Article
Peripherally selective CB1 receptor antagonist improves symptoms of metabolic syndrome in mice
April 09, 2021
Article
Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice
March 25, 2021
Article
Aplnr knockout mice display sex-specific changes in conditioned fear
February 26, 2021
Article
Design, synthesis, and structure-activity relationship studies of (4-alkoxyphenyl)glycinamides and bioisosteric 1,3,4-oxadiazoles as GPR88 agonists
December 10, 2020
Article
Behavioral assessment of rimonabant under acute and chronic conditions
July 15, 2020
Article
Identification of potent pyrazole based APELIN receptor (APJ) agonists
February 15, 2020
Article
Dual-acting cholinesterase-human cannabinoid receptor 2 ligands show pronounced neuroprotection in vitro and overadditive and disease-modifying neuroprotective effects in vivo
October 24, 2019
Article
Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization
August 15, 2019
Article
Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as peripherally restricted inverse agonists of the CB1 receptor
July 11, 2019
Article
A patent update on cannabinoid receptor 1 antagonists (2015-2018)
April 03, 2019
Article
Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists
August 15, 2018
Article
Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake
August 09, 2018