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Search Results

Showing results 1 to 20 of 55.

Article

Novel peripherally selective cannabinoid receptor 1 neutral antagonist improves metabolic dysfunction-associated steatotic liver disease in mice

September 13, 2024
Article

The monoacylglycerol lipase inhibitor ABX-1431 does not improve alcoholic liver disease

August 01, 2024
Article

Discovery of 1,3-disubstituted pyrazole peripheral cannabinoid receptor partial agonists

September 01, 2023
Article

Improvement of the metabolic stability of GPR88 agonist RTI-13951-33: Design, synthesis, and biological evaluation

February 23, 2023
Article

Structure-activity relationship development efforts towards peripherally selective analogs of the cannabinoid receptor partial agonist BAY 59-3074

September 02, 2022
Article

Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor

July 15, 2022
Article

Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies

August 26, 2021
Article

"Photo-Rimonabant": Synthesis and biological evaluation of novel photoswitchable molecules derived from Rimonabant lead to a highly selective and nanomolar "Cis-On" CB1R antagonist

May 05, 2021
Article

Peripherally selective CB1 receptor antagonist improves symptoms of metabolic syndrome in mice

April 09, 2021
Article

Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice

March 25, 2021
Article

Aplnr knockout mice display sex-specific changes in conditioned fear

February 26, 2021
Article

Design, synthesis, and structure-activity relationship studies of (4-alkoxyphenyl)glycinamides and bioisosteric 1,3,4-oxadiazoles as GPR88 agonists

December 10, 2020
Article

Behavioral assessment of rimonabant under acute and chronic conditions

July 15, 2020
Article

Identification of potent pyrazole based APELIN receptor (APJ) agonists

February 15, 2020
Article

Dual-acting cholinesterase-human cannabinoid receptor 2 ligands show pronounced neuroprotection in vitro and overadditive and disease-modifying neuroprotective effects in vivo

October 24, 2019
Article

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization

August 15, 2019
Article

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as peripherally restricted inverse agonists of the CB1 receptor

July 11, 2019
Article

A patent update on cannabinoid receptor 1 antagonists (2015-2018)

April 03, 2019
Article

Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists

August 15, 2018
Article

Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake

August 09, 2018