RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Utilizing artificial neural networks in MATLAB to achieve parts-per-billion mass measurement accuracy with a Fourier transform ion cyclotron resonance mass spectrometer
Williams, D. K., Kovach, A. L., Muddiman, D. C., & Hanck, K. W. (2009). Utilizing artificial neural networks in MATLAB to achieve parts-per-billion mass measurement accuracy with a Fourier transform ion cyclotron resonance mass spectrometer. Journal of the American Society for Mass Spectrometry, 20(7), 1303–1310.
Fourier transform ion cyclotron resonance mass spectrometry has the ability to realize exceptional mass measurement accuracy (MMA); MMA is one of the most significant attributes of mass spectrometric measurements as it affords extraordinary molecular specificity. However, due to space-charge effects, the achievable MMA significantly depends on the total number of ions trapped in the ICR cell for a particular measurement, as well as relative ion abundance of a given species. Artificial neural network calibration in conjunction with automatic gain control (AGC) is utilized in these experiments to formally account for the differences in total ion population in the ICR cell between the external calibration spectra and experimental spectra. In addition, artificial neural network calibration is used to account for both differences in total ion population in the ICR cell as well as relative ion abundance of a given species, which also affords mean MMA values at the parts-per-billion level.