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Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease
Investigators of the Comprehensive Sickle Cell Centers (2011). Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease. British Journal of Haematology, 155(2), 263-267. https://doi.org/10.1111/j.1365-2141.2011.08827.x
Tapered oral dexamethasone for acute chest syndrome (ACS) in sickle cell anaemia was studied using a novel ACS assessment tool and investigational biomarkers. Twelve participants were randomized (mean age 17·3 years) before early study termination. Dexamethasone decreased duration of hospitalization for ACS by 20·8 h compared to placebo (P = 0·024). Rebound pain occurred in both groups (3 dexamethasone versus 1 placebo). Overall, dexamethasone decreased the leucocyte activation biomarker, sL-selectin; however, participants with rebound pain had higher sL-selectin within 24 h of treatment (dexamethasone or placebo). This ACS assessment tool was feasibly applied, and sL-selectin is a promising biomarker of ACS therapy.