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A systematic review of the effect of HIV infection and antiretroviral therapy on the risk of preeclampsia
Adams, J. W. I., Watts, D. H., & Phelps, B. R. (2016). A systematic review of the effect of HIV infection and antiretroviral therapy on the risk of preeclampsia. International Journal of Gynecology & Obstetrics.
Background: The associations between HIV infection, antiretroviral therapy (ART), and pre-eclampsia are unclear.
Objectives: To summarize research and clarify the implications of HIV and ART on pre-eclampsia risk.
Search strategy: MedLine, PubMed, Web of Science, and the Cochrane Library were searched for studies published between 2003 and July 2014, using relevant keywords.
Selection criteria: Full-text review was dependent on the inclusion of pre-eclampsia as an outcome and original data.
Data collection and analysis: Data for population, confounders, limitations, and measures of association were qualitatively assessed.
Main results: Among 550 records identified, 70 were screened, and 13 were included. Five of the nine studies comparing pre-eclampsia risk between women with and without HIV infection found no significant difference; only one found that women living with HIV were more likely to experience pre-eclampsia. Two studies found that women living with HIV who were receiving ART at conception were more likely to experience pre-eclampsia than were those not receiving ART at conception. Two studies reported that pre-eclampsia rates did not differ by ART regimen.
Conclusions: There is insufficient evidence to conclude that women living with HIV and receiving ART have a higher risk of pre-eclampsia than do women without HIV infection; further research is needed to assess the association between ART and pre-eclampsia.
