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Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol
Bisogno, T., Burston, JJ., Rai, R., Allara, M., Saha, B., Mahadevan, A., Razdan, RK., Wiley, J., & Di Marzo, V. (2009). Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol. ChemMedChem, 4(6), 946-950. https://doi.org/10.1002/cmdc.200800442
Biosynthesis Inhibition: O-5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2-arachidonoylglycerol, was synthesized and found to be potent (IC50=100?nm) and selective versus other proteins and enzymes of the endocannabinoid system in?vitro and active in?vivo at reducing food intake in mice.