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Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring
Wallgren, J., Vikingsson, S., Johansson, A., Josefsson, M., Green, H., Dahlén, J., Wu, X., & Konradsson, P. (2017). Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring. Tetrahedron Letters, 58(15), 1456-1458. https://doi.org/10.1016/j.tetlet.2017.02.077
Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one major metabolite of AKB-48, a new illicit psychoactive substance with a hydroxyl group at a secondary carbon of the adamantyl ring.
