Synthesis of [12-3H]-(+/-)-calanolide A

Ken S. Rehder; John A. Kepler; Maria K. Hristova-Kazmierski; Ken S. Rehder; Maria K. Hristova-Kazmierski; John A. Kepler

Synthesis of [12-3H]-(+/-)-calanolide A

Rehder, K. S., Hristova-Kazmierski, M., & Kepler, J. (1996). Synthesis of [12-3H]-(+/-)-calanolide A. Journal of Labelled Compounds and Radiopharmaceuticals, 38(12), 1077-1081. https://doi.org/10.1002/(SICI)1099-1344(199612)38:12<1077::AID-JLCR930>3.0.CO;2-%23

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Abstract

[12‐3H]‐(±)‐Calanolide A (9) was synthesized in five steps from readily available phloroglucinol (1). Stereoselective Luche reduction of transketone 8 with cerium(III) chloride and sodium borotritide in methanol gave 338 μCi of 9 with a specific activity of 63.0 mCi/mmol.