RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Standardized entrainment tubes for the evaluation of pharmaceutical dry powder dispersion
Louey, MD., Van Oort, M., & Hickey, A. (2006). Standardized entrainment tubes for the evaluation of pharmaceutical dry powder dispersion. Journal of Aerosol Science, 37(11), 1520-1531. https://doi.org/10.1016/j.jaerosci.2006.04.002
A series of standardized entrainment tubes (SETs) were designed to provide a method for evaluation of aerosol dispersion of pharmaceutical powders. The range of specific resistances (R-D) provided by the SETs encompassed those of commercial DPIs. The airflow conditions within the SET's were characterized in terms of pressure drop (Delta P), power, Reynold's number (Re) and shear stress (tau(s)) at airflow rates of 28.3 and 60 L/min. The aerosol performance of a commercial powder formulation (Ventolin Rotacaps(TM)) obtained using the SETs was measured by cascade impaction; and characterized using emitted dose (ED), fine particle mass (FPM), mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD). The use of SETs allowed the aerosol performance of the powder formulation to be measured under well defined geometry and flow conditions. Good reproducibility in ED, FPM and MMAD results were obtained from SETs. Comparable values were obtained from SETs at similar resistance levels to the commercial inhaler devices (Rotahaler(TM) and Inhalator(TM)). The SETs enabled examination of fundamental relationships between airflow conditions and aerosol performance. (C) 2006 Elsevier Ltd. All rights reserved
