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Risk factor reversal in studies of infectious disease
Making counterintuitive results intuitive again
Kaufman, J., Banack, H., Adams, J. W. I., Marshall, B., & Stovitz, S. (2019). Risk factor reversal in studies of infectious disease: Making counterintuitive results intuitive again. Sexually Transmitted Diseases. https://doi.org/10.1097/OLQ.0000000000000911
A previously published study reported the seemingly paradoxical finding that men who have sex with men status was strongly protective and recent sexual abstinence strongly deleterious in relation to mortality prognosis. We explain why these results are entirely logical and that the counterintuitive direction of the effects derives from the comparison group implied by the study design.
