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Preparation of High Specific Activity [15,16-3H]-7-Benzylidenenaltrexone

Lewin, A., & Lamb, P. (1996). Preparation of High Specific Activity [15,16-3H]-7-Benzylidenenaltrexone. Journal of Labelled Compounds and Radiopharmaceuticals, 38(2), 203-205. https://doi.org/10.1002/(SICI)1099-1344(199602)38:2<203::AID-JLCR828>3.0.CO;2-D

Abstract

The preparation of the δ1‐specific ligand 7‐benzylidenenaltrexone (BNTX), labeled with tritium at high specific activity (14.4 Ci/mmol) was prepared in 33% yield and >98% purity by the aldol condensation of high specific activity [15,16‐3H]naltrexone with benzaldehyde at high dilution.

10.1002/(SICI)1099-1344(199602)38:2<203::AID-JLCR828>3.0.CO;2-D

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