Preparation of carbon-14 labeled hair dyes

Abstract

Friedel-Crafts acylation of [U-C-14]p-dichlorobenzene with 3,6-dichlorophthalic anhydride in aluminum bromide melt followed by oleum cyclization afforded [U-C-14]-1,4,5,8-tetrachloroanthraquinone. Potassium fluoride mediated amidosulfonation followed by hydrolysis gave [U-C-14]-1,4,5,8-tetraaminoanthraquinone with specific activity 39.7 mCi/mmol in 5.6% radiochemical yield.