A practical, laboratory-scale synthesis of perampanel

Abstract

The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1',6'-dihydro-6'-oxo-1-phenyl-(2',3'-bipyridin)-5'-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials. The synthesis was carried out on a laboratory scale with no specialized equipment, and involved only two chromatographic purifications.