RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.

Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales

Ayers, S., Graf, TN., Adcock, A., Kroll, DJ., Shen, Q., Swanson, SM., Wani, M., Darveaux, BA., Pearce, CJ., & Oberlies, NH. (2011). Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales. Tetrahedron Letters, 52(40), 5128-5130.

Abstract

A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 mu M, depending on the cell line tested. (C) 2011 Elsevier Ltd. All rights reserved

Publications Info

To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request.