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New biphenyl compounds with DNA strand-scission activity from Clusia paralicola
Seo, E.-K., Huang, L., Wall, M., Wani, M., Navarro, H., Mukherjee, R., Farnsworth, NR., & Kinghorn, AD. (1999). New biphenyl compounds with DNA strand-scission activity from Clusia paralicola. Journal of Natural Products, 62(11), 1484-1487. https://doi.org/10.1021/np980509w
Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1?3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.