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Multidimensional gas chromatography-mass spectrometry is an emerging technology that can offer improved separation, reproducibility, and sensitivity. For clinical and forensic toxicologists who must analyze complex biological matrices for drugs and other compounds, it is an analytical option that warrants investigation.
Analytes of interest are often present in trace amounts in matrices predominated by other compounds. This creates a problem of co-elution and low analyte-to-background signal, which is difficult to detect and quantify using traditional gas chromatography- mass spectrometry (GC-MS). Tandem mass spectrometry (MS-MS, MS-MS-MS) was introduced to improve sensitivity, but many laboratories cannot afford these instruments for routine analyses. GCGC- MS offers comparable chromatographic improvements at less expense.
