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The Multisite Family Study on Incarceration, Partnering and Parenting documented the implementation and effectiveness of family-strengthening programming for incarcerated and reentering men and their intimate or coparenting partners. The findings presented in this issue use data collected for the impact study and qualitative substudy, which provide detailed information on the experiences of couples before, during, and after the male partner’s incarceration. This article describes the methodology and sample characteristics for the impact study, which included longitudinal interviews with nearly 2,000 couples in five states, and the qualitative substudy, which included in-depth interviews with 170 impact sample members in three states.