Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

Megan Alene Grabenauer; Nikalet Everson; Kenya Yniguez; Lauren Loop; Horacio Lazaro; Briana Belanger; Grant Koch; Jordan Bach; Aashrita Manjunath; Ryan Schioldager; Jarvis Law; Megan Grabenauer; Scott Eagon

Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

Everson, N., Yniguez, K., Loop, L., Lazaro, H., Belanger, B., Koch, G., Bach, J., Manjunath, A., Schioldager, R., Law, J., Grabenauer, M., & Eagon, S. (2019). Microwave synthesis of 1-aryl-1H-pyrazole-5-amines. Tetrahedron Letters, 60(1), 72-74. https://doi.org/10.1016/j.tetlet.2018.11.060

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Abstract

A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1 M HCl at 150 °C was developed in order to provide products in a matter of minutes with minimal purification. Most reactions are complete in only 10 min and can be isolated via a simple filtration without the need for further purification by column chromatography or recrystallization. This method tolerates a range of functional groups and can be performed on milligram to gram scales.