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Methods and compositions for the modulation of chorismate synthase and chorismate mutase expression or activity in plants
Boyes, DC., Davis, KR., Woessner, JP., Gorlach, J., Hamilton, C., Hoffman, NE., Kloti, AS., Zayed, A., & Ascenzi, RA. (2004). Methods and compositions for the modulation of chorismate synthase and chorismate mutase expression or activity in plants. (U.S. Patent No. 6800459). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6800459
The present inventors have discovered that chorismate mutase and chorismate synthase are essential for plant growth. Specifically, the inhibition of chorismate mutase or chorismate synthase gene expression in plant seedlings results in severe chlorosis, reduced growth and developmental abnormalities. The inventors have proven that chorismate synthase and chorismate mutase can be used as targets for the identification of herbicides. Thus, the invention provides methods for the identification of chemicals that modulate chorismate synthase and chorismate mutase biochemical reactions. The methods of the invention are useful for the identification of herbicides and for the inhibition of plant growth and development.
