RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Metallation/Reduction as a New Approach to Tritium Labeling. The Synthesis of [3H]Ibogaine
Seltzman, H., Odear, D. F., Laudeman, C., Carroll, F., & Wyrick, C. (1994). Metallation/Reduction as a New Approach to Tritium Labeling. The Synthesis of [3H]Ibogaine. Journal of Labelled Compounds and Radiopharmaceuticals, 34(4), 367-375. https://doi.org/10.1002/jlcr.2580340408
A new method is presented for the tritiation of aryl compounds with tritium gas which is conducted on the underivatized substrate. Combined directed ortho metallation and facile reduction of the carbonpotassium bond affords incorporation of tritium at high specific activity under mild conditions. The metallation/reduction method is demonstrated for the preparation of [3H]ibogaine.