Melatonin and agomelatine for preventing seasonal affective disorder

Linda J. Lux; Gerald Gartlehner; Amy M. Greenblatt; A Kaminski-Hartenthaler; B Nussbaumer; Catherine Forneris; Laura Morgan; BN Gaynes; JH Sonis; Amy M. Greenblatt; J Wipplinger; Linda J. Lux; D Winkler; Megan G. Van Noord; J Hofmann; Gerald Gartlehner

Melatonin and agomelatine for preventing seasonal affective disorder

Kaminski-Hartenthaler, A., Nussbaumer, B., Forneris, CA., Morgan, L., Gaynes, BN., Sonis, JH., Greenblatt, A., Wipplinger, J., Lux, L., Winkler, D., Van, N., Hofmann, J., & Gartlehner, G. (2015). Melatonin and agomelatine for preventing seasonal affective disorder. Cochrane Database of Systematic Reviews, 11, CD0211271. https://doi.org/10.1002/14651858.CD011271.pub2

Copy citation

Abstract

No available methodologically sound evidence indicates that melatonin or agomelatine is or is not an effective intervention for prevention of SAD and improvement of patient-centred outcomes among adults with a history of SAD. Lack of evidence clearly shows the need for well-conducted, controlled studies on this topic. A well-conducted RCT of melatonin or agomelatine for prevention of SAD would assess the comparative benefits and risks of these interventions against others currently used to treat the disorder.