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To the Editor—I have read with interest the article by Weinstein et al. “Modeling for Health Care and Other Policy Decisions: Uses, Roles, and Validity.” I agree with the authors that this is a controversial area, but I am not sure that the authors have considered what I would see as the fundamental questions in this debate: Who are the endusers of “modeled” cost-effectiveness claims and what are their information needs? Indeed, should the focus of pharmacoeconomics be on making recommendations as to the cost-effective use of medical technologies, or should we be looking at the wider picture?