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Human papillomavirus is the most common sexually transmitted infection in the United States. Males have been identified as playing a major role in the transmission and acquisition of human papillomavirus, thus placing themselves and their partners at greater risk for certain types of cancer. Through this study the authors sought to develop a better understanding of college males' perceptions regarding human papillomavirus and the human papillomavirus vaccine. Results provide an initial understanding of college males' perceptions of human papillomavirus and the vaccine as a means of establishing a baseline for determining appropriate health communication messages.