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International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC topic No. 2.
Heterozygous effects of multilocus deletions
De Serres, F. (1988). International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC topic No. 2. Heterozygous effects of multilocus deletions. Mutation Research - Reviews in Genetic Toxicology, 196(1), 95-99. https://doi.org/10.1016/0165-1110(88)90030-9
In order to determine the potential human health risks of exposure to mutagenic environmental agents for the induction of specific-locus mutations, it is essential to use model systems capable of detecting the full range of genetic damage that will give rise to such mutations as well as to determine the genetic consequences of their successful transmission through the germline to F 1 progeny. Specific-locus mutations result from two general types of genetic damage: (1) intragenic alterations resulting from changes within the gene ranging from single base-pair substitutions or single base-pair additions or deletions (gene/point mutations) to large intralocal deletions of many base pairs, and (2) extragenic alterations resulting