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Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies
Moody, M. A., Pedroza-Pacheco, I., Vandergrift, N. A., Chui, C., Lloyd, K. E., Parks, R., Soderberg, K. A., Ogbe, A. T., Cohen, M. S., Liao, H.-X., Gao, F., McMichael, A. J., Montefiori, D. C., Verkoczy, L., Kelsoe, G., Huang, J., Shea, P. R., Connors, M., Borrow, P., & Haynes, B. F. (2016). Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies. Science immunology, 1(1), Article aag0851. https://doi.org/10.1126/sciimmunol.aag0851
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.
