RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor
Schmink, J. R., Kormos, C. M., Devine, W. G., & Leadbeater, N. E. (2010). Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor. Organic Process Research and Development, 14(1), 205-214. https://doi.org/10.1021/op900287j
A new batch microwave reactor has been evaluated in the context of palladium-mediated transformations, condensation reactions, nucleophilic aromatic substitution reactions, and alkylations. Importantly, a linear scaling approach was taken, no changes being made to the protocol when moving from the small, developmental scale to larger scales. In some cases reactions were scaled over 18,000-fold when moving from small (0.1-1 nmol) to large (1-18 mol) runs.