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Examining the effects of age on health outcomes of chronic obstructive pulmonary disease
Results from the genetic epidemiology of chronic obstructive pulmonary disease study and evaluation of chronic obstructive pulmonary disease longitudinally to identify predictive surrogate endpoints cohorts
Parulekar, AD., Martinez, C., Tsai, C-L., Locantore, N., Atik, M., Yohannes, AM., Kao, CC., Al-Azzawi, H., Mohsin, A., Wise, RA., Foreman, MG., Demeo, DL., Regan, EA., Make, BJ., Boriek, AM., Wiener, L. E., & Hanania, NA. (2017). Examining the effects of age on health outcomes of chronic obstructive pulmonary disease: Results from the genetic epidemiology of chronic obstructive pulmonary disease study and evaluation of chronic obstructive pulmonary disease longitudinally to identify predictive surrogate endpoints cohorts. Journal of the American Medical Directors Association, 18(12), 1063-1068. https://doi.org/10.1016/j.jamda.2017.09.028
Rationale: The prevalence of chronic obstructive pulmonary disease (COPD) and its associated comorbidities increase with age. However, little is understood about differences in the disease in patients over 65 years of age compared with younger patients. Objectives: To determine disease characteristics of COPD and its impact in older patients compared with younger patients.
Methods: We examined baseline characteristics of patients with COPD (global obstructive lung disease stage IIeIV) in 2 large cohorts: Genetic Epidemiology of COPD Study (COPDGene) and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). We compared demographics, indices of disease severity, prevalence of comorbidities, exacerbation frequency, and quality of life scores in patients
Results: In the COPDGene cohort, older patients (n = 1663) had more severe disease as measured by forced expiratory volume in 1 second (1.22 vs 1.52 L, P
Conclusions: Despite greater severity of illness, older patients with COPD had better quality of life and reported fewer exacerbations than younger patients. Although this observation needs to be explored further, it may be related to the fact that older patients change their expectations and learn to adapt to their disease. (C) 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.