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Evaluation of the fish acute toxicity test for pesticide registration
Ceger, P., Allen, D., Blankinship, A., Choksi, N., Daniel, A., Eckel, W., Hamm, J., Harwood, D. E., Johnson, T., Kleinstreuer, N., Sprankle, C. S., Truax, J., & Lowit, M. (2023). Evaluation of the fish acute toxicity test for pesticide registration. Regulatory Toxicology and Pharmacology, 139, Article 105340. https://doi.org/10.1016/j.yrtph.2023.105340
The U.S. Environmental Protection Agency (USEPA) uses the in vivo fish acute toxicity test to assess potential risk of substances to non-target aquatic vertebrates. The test is typically conducted on a cold and a warm freshwater species and a saltwater species for a conventional pesticide registration, potentially requiring upwards of 200 or more fish. A retrospective data evaluation was conducted to explore the potential for using fewer fish species to support conventional pesticide risk assessments. Lethal concentration 50% (LC50) values and experimental details were extracted and curated from 718 studies on fish acute toxicity submitted to USEPA. The LC50 data were analysed to determine, when possible, the relative sensitivity of the tested species to each pesticide. One of the tested freshwater species was most sensitive in 85% of those cases. The tested cold freshwater species was the most sensitive overall among cases with established relative sensitivity and was within 3X of the LC50 value of the most sensitive species tested in 98% of those cases. The results support potentially using fewer than three fish species to conduct ecological risk assessments for the registration of conventional pesticides.
