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Endovascular therapy for advanced post-thrombotic syndrome
Proceedings from a multidisciplinary consensus panel
Vedantham, S., Kahn, S. R., Goldhaber, S. Z., Comerota, A. J., Parpia, S., Meleth, S., Earp, D., Williams, R., Sista, A. K., Marston, W., Rathbun, S., Magnuson, E. A., Razavi, M. K., Jaff, M. R., & Kearon, C. (2016). Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel. Vascular Medicine, 21(4), 400-407. https://doi.org/10.1177/1358863X16650747
Patients with advanced post-thrombotic syndrome (PTS) and chronic iliac vein obstruction suffer major physical limitations and impairment of health-related quality of life. Currently there is a lack of evidence-based treatment options for these patients. Early studies suggest that imaging-guided, catheter-based endovascular therapy can eliminate iliac vein obstruction and saphenous venous valvular reflux, resulting in reduced PTS severity; however, these observations have not been rigorously validated. A multidisciplinary expert panel meeting was convened to plan a multicenter randomized controlled clinical trial to evaluate endovascular therapy for the treatment of advanced PTS. This article summarizes the findings of the panel, and is expected to assist in developing a National Institutes of Health-sponsored clinical trial and other studies to improve the care of patients with advanced PTS.