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The Brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) - Four-stage translation and validation
Ribeiro-Oliveira, A., Mol, S. S., Twiss, J., Alencar, G. A., Carvalho Miranda, P. A., Naves, L. A., Azevedo, M. F., Basilio, F. M. A., Boguszewski, C. L., Nogueira, K. C., Vilar, L., Koltowska-Haggstrom, M., & McKenna, S. P. (2010). The Brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) - Four-stage translation and validation. Arquivos Brasileiros de Endocrinologia e Metabologia, 54(9), 833-841. https://doi.org/10.1590/S0004-27302010000900010
Objective: This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients. Materials and methods: The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups. Results: The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p <0.01) and QoL (p <0.01). Conclusions:The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid. Arq Bras Endocrine! Metab. 2010;54(9):833-41