RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Bioreactor technology for cell therapy manufacturing in regenerative medicine
Zhang, H., Kent, D. E., Albanna, M., Lhu, L., Sun, X. S., Eaker, S., & Somara, S. (2021). Bioreactor technology for cell therapy manufacturing in regenerative medicine. Current Stem Cell Reports, 7(4), 212-218. https://doi.org/10.1007/s40778-021-00200-x
Purpose of Review It is a great challenge to scale up current cell therapy processes developed in 2D systems, and bioreactor technology could play an essential role in the scale-up of cell therapeutic products.
Recent Findings Cell quality is critical to the therapeutic efficacy and their critical quality attributes (CQAs) are tightly related to their manufacturing processes. Employment of appropriate bioreactors for cellular products would enhance the productivity, reduce the cost as well as ensure the product CQAs.
Summary The article reviews current commercially available bioreactors and their applications for regenerative therapeutic products. Regulatory, quality, and manufacturing aspects of these bioreactors are discussed.
