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Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study
Loeser, R. F., Pathmasiri, W., Sumner, S., McRitchie, S., Beavers, D., Saxena, P., Nicklas, BJ., Jordan, J., Guermazi, A., Hunter, DJ., & Messier, SP. (2016). Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study. Osteoarthritis and Cartilage, 24(8), 1479-1486. https://doi.org/10.1016/j.joca.2016.03.011
INTRODUCTION: Metabolic factors may contribute to osteoarthritis (OA). This study employed metabolomics analyses to determine if differences in metabolite profiles could distinguish people with knee OA who exhibited radiographic progression. METHODS: Urine samples obtained at baseline and 18 months from overweight and obese adults in the Intensive Diet and Exercise for Arthritis (IDEA) trial were selected from two subgroups (n = 22 each) for metabolomics analysis: a group that exhibited radiographic progression (>/=0.7 mm decrease in joint space width, JSW) and an age, gender, and body mass index (BMI) matched group who did not progress (