Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties

Hernan A. Navarro; Scott P. Runyon; Scott P. Runyon; M Rogawski; Edgar Cook; John Kepler; Hernan A. Navarro; R Kaminski; M Orr

Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties

Runyon, S., Rogawski, M., Cook, E., Kepler, J., Navarro, H., Kaminski, R., & Orr, M. (2016). Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties. (U.S. Patent No. 9,518,080). http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9,518,080.PN.&OS=PN/9,518,080&RS=PN/9,518,080

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Abstract

This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage. ##STR00001##