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This article addresses the prevalence of Alzheimer’s Disease and related dementias (ADRD) and racial and ethnic disparities among people with ADRD in the United States. Disparities among blacks and Hispanics compared with non-Hispanic whites concerning ADRD are discussed, including mortality, use of long-term services and supports, healthcare expenditures, quality of care, and caregiving. The literature suggests numerous underlying causes, including genetics, socioeconomic factors, cultural differences, lack of culturally competent clinicians, and discrimination. Although these disparities are well known, little is known about the effectiveness of various strategies, such as cultural competence training, to address these differences.