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α-synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease
Gatto, N. M., Rhodes, S. L., Manthripragada, A. D., Bronstein, J., Cockburn, M., Farrer, M., & Ritz, B. (2010). α-synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease. Neuroepidemiology, 35(3), 191-195. https://doi.org/10.1159/000315157
Background: Although of great interest and suggested in prior reports, possible alpha-synuclein (SNCA) gene-environment interactions have not been well investigated in humans. Methods: We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of SNCA variations and two important environmental factors, pesticide exposures and smoking. Results/Conclusions: Similar to recent meta-and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the SNCA REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset