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7alpha, 11beta-Dimethyl-19-nortestosterone, made by 1,6-methyl addition to 17beta-acetoxy- 11beta-methylestra-4,6-dien-3-one, was a highly potent and selective androgen response modulator, with enhanced androgen receptor binding, androgenic activity and anabolic: androgenic ratio over its two monomethyl homologs. (C) 2004 Elsevier Ltd. All rights reserved