Scott Runyon

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Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene

Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis

Arylpiperazine Opioid Receptor Antagonists

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dim ethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profi

Discovery of novel proline-based neuropeptide FF receptor antagonists

GPCR activation: Principle component analysis as a diagnostic signature correlated with SAR

Potent and selective tetrahydroisoquinoline kappa opioid receptor antagonists of lead compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic)

Formulation and characterization of conjugate vaccines to reduce opioid use disorders suitable for pharmaceutical manufacturing and clinical evaluation

Discovery of a novel small molecule agonist scaffold for the APJ receptor

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells

Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

Indenopyride Derivative RTI-4587-073(1): A Candidate for Male Contraception in Stallions

Acute and chronic effects of a contraceptive compound RTI-4587-073(l) on testicular histology and endocrine function in miniature horse stallions

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor

Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product

Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl ]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity

The Immunological and Pharmacokinetic Evaluation of Lipid-PLGA Hybrid Nanoparticle-Based Oxycodone Vaccines

Development of novel neuroactive steroids for the potential treatment of Neurological Disorders

Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists