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Search Results

Showing results 1 to 20 of 70.

Article

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization

August 15, 2019
Article

The monoacylglycerol lipase inhibitor ABX-1431 does not improve alcoholic liver disease

August 01, 2024
Patent

Apelin receptor (APJ) agonists and uses thereof

August 02, 2022
Article

Dual-acting cholinesterase-human cannabinoid receptor 2 ligands show pronounced neuroprotection in vitro and overadditive and disease-modifying neuroprotective effects in vivo

October 24, 2019
Article

Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice

March 25, 2021
Article

A disease-relevant high-content screening assay to identify anti-inflammatory compounds for use in cystic fibrosis

December 01, 2010
Article

Peripherally selective CB1 receptor antagonist improves symptoms of metabolic syndrome in mice

April 09, 2021
Chapter

Metabolic profiling of CB1 neutral antagonists: (Chapter 9)

July 01, 2017
Article

Peripherally Selective Diphenyl Purine Antagonist of the CB1 Receptor

September 27, 2013
Article

Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis

October 01, 2017
Article

Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake

August 09, 2018
Article

Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dim ethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profi

September 11, 2014
Article

Discovery of a novel small molecule agonist scaffold for the APJ receptor

August 15, 2016
Article

Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies

August 26, 2021
Article

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents

October 01, 2015
Article

"Photo-Rimonabant": Synthesis and biological evaluation of novel photoswitchable molecules derived from Rimonabant lead to a highly selective and nanomolar "Cis-On" CB1R antagonist

May 05, 2021
Article

Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice

November 01, 2012
Article

Altered Biogenesis of DeltaF508-CFTR Following Treatment with Doxorubicin

April 01, 2007
Article

Increased functional cell surface expression of CFTR and Delta F508-CFTR by the anthracycline doxorubicin

May 01, 2001
Patent

Diaryl purine derivatives with improved bioavailability

June 30, 2020