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Showing results 1 to 20 of 70.
Article
Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization
August 15, 2019
Article
The monoacylglycerol lipase inhibitor ABX-1431 does not improve alcoholic liver disease
August 01, 2024
Patent
Apelin receptor (APJ) agonists and uses thereof
August 02, 2022
Article
Dual-acting cholinesterase-human cannabinoid receptor 2 ligands show pronounced neuroprotection in vitro and overadditive and disease-modifying neuroprotective effects in vivo
October 24, 2019
Article
Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice
March 25, 2021
Article
A disease-relevant high-content screening assay to identify anti-inflammatory compounds for use in cystic fibrosis
December 01, 2010
Article
Peripherally selective CB1 receptor antagonist improves symptoms of metabolic syndrome in mice
April 09, 2021
Chapter
Metabolic profiling of CB1 neutral antagonists: (Chapter 9)
July 01, 2017
Article
Peripherally Selective Diphenyl Purine Antagonist of the CB1 Receptor
September 27, 2013
Article
Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis
October 01, 2017
Article
Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake
August 09, 2018
Article
Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dim ethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profi
September 11, 2014
Article
Discovery of a novel small molecule agonist scaffold for the APJ receptor
August 15, 2016
Article
Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies
August 26, 2021
Article
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents
October 01, 2015
Article
"Photo-Rimonabant": Synthesis and biological evaluation of novel photoswitchable molecules derived from Rimonabant lead to a highly selective and nanomolar "Cis-On" CB1R antagonist
May 05, 2021
Article
Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice
November 01, 2012
Article
Altered Biogenesis of DeltaF508-CFTR Following Treatment with Doxorubicin
April 01, 2007
Article
Increased functional cell surface expression of CFTR and Delta F508-CFTR by the anthracycline doxorubicin
May 01, 2001
Patent
Diaryl purine derivatives with improved bioavailability
June 30, 2020