Chunyang Jin

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Intramolecular cyclization reactions of carbonyl derivatives of hydroxysulfones

Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities

Convenient synthesis of tolcapone, a selective catechol-O-methyltransferase inhibitor

New intramolecular alkylation and Michael addition reactions of hydroxysulfone derivatives–stereoselective preparation of functionalized cyclic ethers

Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice

Discovery and characterization of the first nonpeptide antagonists for the relaxin-3/RXFP3 system

Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter

Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor

Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes

Synthesis and structure-activity relationship of 3ß-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3ß-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters

Rxfp3 small molecule antagonist decreases alcohol self-administration in rats

Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake

Improved synthesis of N-desmethylcitalopram and N,N-didesmethylcitalopram

Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists

Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters

A short and efficient synthesis of 3-{2-[2-(bromomethyl)thiazol-4-yl]ethynyl}-5-fluorobenzonitrile:: A precursor for PET radioligand [F-18]SP203

Synthesis of ether-linked fluorocarbon surfactants and their aggregational properties in organic solvents

Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies

Practical synthesis of p-aminophenethylspiperone (NAPS), a high-affinity, selective D-2-dopamine receptor antagonist

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2–induced resistance