Scott Runyon

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Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

Discovery of novel proline-based neuropeptide FF receptor antagonists

Development of a peripherally restricted cb1 receptor antagonist for alcoholic steatosis

Arylpiperazine Opioid Receptor Antagonists

Simple tetrahydroisoquinolines are potent and selective kappa opioid receptor antagonists

Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation

GPCR activation: Principle component analysis as a diagnostic signature correlated with SAR

Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties

1-substituted 4-arylpiperazine as kappa opioid receptor antagonists

Design, synthesis, and biological evaluation of structurally rigid analogues of 4-(3-Hydroxyphenyl)piperidine opioid receptor antagonists

RECENT DEVELOPMENTS IN NEUROPEPTIDE S RECEPTOR (NPSR) RESEARCH

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl)}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a selective antagonist for the rat neurotensin receptor type 2

Discovery of a novel small molecule agonist scaffold for the APJ receptor

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres

Novel 17-substituted neuroactive steroids for the potential treatment of neurological disorders

Arylpiperazine Opioid Receptor Antagonists

The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence

Regulation of the apelinergic system and its potential in cardiovascular disease: Peptides and small molecules as tools for discovery

Composition and method for neuropeptide S receptor (NPSR) antagonists

Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents