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Synthesis of the isomers of (1R)-3-(phenylthio)tropane-2-carboxylic acid methyl ester. A new class of ligands for the dopamine transporter
Thiruvazhi, M., Abraham, P., Kuhar, MJ., & Carroll, F. (1997). Synthesis of the isomers of (1R)-3-(phenylthio)tropane-2-carboxylic acid methyl ester. A new class of ligands for the dopamine transporter. Chemical Communications, (6), 555-556.
The syntheses of all four isomers of (1R)-3-(phenylthio)tropane-2-carboxylic acid methyl ester are described; the 2 beta,3 beta-isomer shows high affinity for the cocaine binding site on the dopamine transporter