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Synthesis of carnosine-d7 and anserine-d4 for use as internal standards in liquid chromatography-mass spectrometry
Gopinathan, M., Jin, C., & Rehder, K. (2009). Synthesis of carnosine-d7 and anserine-d4 for use as internal standards in liquid chromatography-mass spectrometry. Synthetic Communications, 39(22), 3973-3981. https://doi.org/10.1080/00397910902838987
A convenient synthesis of carnosine-d7 and anserine-d4 is described. Coupling of N-Boc-beta-alanine-d4 with L-histidine-d3 or 1-methyl-L-histidine using isobutyl chloroformate afforded the corresponding Boc-protected dipeptide. Subsequent Boc group deprotection with hydrochloric acid yielded carnosine-d7 and anserine-d4 in 46% and 69% overall yield, respectively
