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Syntheses of H-3-labeled, C-14-labeled, and H-2(4)-labeled SCH 444877, phosphodiesterase type 5 inhibitors
Ren, S., Hesk, D., McNamara, P., Koharski, D., & Hendershot, S. (2013). Syntheses of H-3-labeled, C-14-labeled, and H-2(4)-labeled SCH 444877, phosphodiesterase type 5 inhibitors. Journal of Labelled Compounds and Radiopharmaceuticals, 56(9-10), 480-484. https://doi.org/10.1002/jlcr.3080
The syntheses of [H-3]SCH 444877, [H-2(4)]SCH 444877, and [C-14]SCH 444877 are described. [H-3]SCH 444877 was prepared in three steps from tritium gas. [H-2(4)]SCH 444877 was synthesized from [H-2(4)]ethanolamine in four steps with an overall yield of 40%. [C-14]SCH 444877 was prepared from barium [C-14]cyanamide in 10 steps with an overall yield of 8.1%.Copyright (c) 2013 John Wiley & Sons, Ltd.
