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RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter

Dworkin, SI., Lambert, P., Sizemore, GM., Carroll, F., & Kuhar, MJ. (1998). RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter. Synapse, 30(1), 49-55.

Abstract

RTI-113 [3 beta-(4-chlorophenyl)tropan-2 beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat, at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT. Synapse 30:49-55, 1998. (C) Wiley-Liss, Inc., Inc

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