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A naturalistic study of clinical and genetic factors and post-treatment depressive symptom trajectory
Trautmann, N., Foo, J. C., Frank, J., Witt, S. H., Streit, F., Treutlein, J., Von Heydendorff, S. C., Gilles, M., Forstner, A. J., Ebner-priemer, U., Nöthen, M. M., Deuschle, M., Rietschel, M., & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2018). Response to therapeutic sleep deprivation: A naturalistic study of clinical and genetic factors and post-treatment depressive symptom trajectory. Neuropsychopharmacology, 43(13), 2572-2577. https://doi.org/10.1038/s41386-018-0092-y
Research has shown that therapeutic sleep deprivation (SD) has rapid antidepressant effects in the majority of depressed patients. Investigation of factors preceding and accompanying these effects may facilitate the identification of the underlying biological mechanisms. This exploratory study aimed to examine clinical and genetic factors predicting response to SD and determine the impact of SD on illness course. Mood during SD was also assessed via visual analogue scale. Depressed inpatients (n = 78) and healthy controls (n = 15) underwent similar to 36 h of SD. Response to SD was defined as a score of depression.
