RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain
Akke, M., Liu, J., Cavanagh, J., Erickson, HP., & Palmer III, AG. (1998). Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. Nature Structural and Molecular Biology, 5(1), 55-59.
A novel off-resonance rotating-frame N-15 NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 mu s in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the beta-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the beta-sheets. Flexibility of the loop containing the Arg-Gly-Asp (RGD) tripeptide may affect the accessibility of this motif in protein-protein interactions.